1 st July 2016 Apex City Quay Hotel West Victoria Dock

1: The evidence base for intervention with respect to smoking and consanguinity. Meta-analyses reveal that passive smoking and consanguinity ARE both risk factors in OFC. Mossey, P.A. “Passive smoking in the etiology of non-syndromic orofacial clefts: a systematic review and meta-analysis”. Sabbagh HJ, Hassan MH, Innes NP, Elkodary HM, Little J, Mossey PA Data extraction from studies reporting maternal passive smoking and NSOFC was implemented without language restrictions. Risks of bias in the identified studies were assessed and this information was used in sensitivity analyses to explain heterogeneity. Meta-analysis and metaregression of the extracted data were performed. Egger's test was used to test for small study effects. Fourteen eligible articles were identified. Maternal passive smoking exposure was associated with a twofold increase in risk of NSOFC (odds ratio: 2.11, 95% confidence interval: 1.54– 2.89); this was apparent for both cleft lip with and without palate (OR: 2.05, 95% CI: 1.27–3.3) and cleft palate (OR: 2.11, 95% CI: 1.23–3.62). There was substantial heterogeneity between studies. In the studies that provided data enabling crude and adjusted odd ratios to be compared, adjustment for potential confounders attenuated the magnitude of association to about a 1.5-fold increase in risk. “Parental Consanguinity and Nonsyndromic Orofacial Clefts in Children: A Systematic Review and Meta-Analyses”. Sabbagh HJ, Hassan MH, Innes NP, Al Baik A, Mossey PA Objective: To assess whether individuals born to consanguineous parents had a higher frequency of nonsyndromic orofacial clefts compared with those with no parental consanguinity. Design: A prespecified plan for a search strategy, inclusion/exclusion criteria, and data extraction from studies reporting consanguinity in relation to nonsyndromic orofacial clefts (NSOFC) was carried out. Papers reporting observational studies with control populations were included, without language restrictions, and these reports were assessed for quality. Sensitivity analyses using subgroups, homogeneity evaluation, and assessment of publication bias were carried out, and meta-analyses of extracted data were performed. Results: Sixteen studies fulfilled the selection criteria and were included in the metaanalyses. There were statistically significant relationships between consanguinity and NSOFC for all 16 studies combined (P = .0003), with odds ratio (OR) = 1.83 and 95% confidence interval (CI) (1.31, 2.54); 10